South Carolina is a coastal state in the Southeastern United States. Home to cities like Charleston, Myrtle Beach, and Hilton Head Island, there are plenty of travel destinations to explore. In this article, we have handpicked the best weekend getaways in South Carolina with top-notch comfort and tranquility.
- Sea Pines Resort
- voco the Shelby
- Wild Dunes Resort
- French Quarter Inn
- The George Hotel
- Beach House Hilton Head Island
- The Dewberry
Sea Pines Resort
Sea Pines Resort is one of the finest weekend getaways in the Southeast. Located on the coast of Hilton Head Island, it is a Lowcountry sanctuary for beach and golf lovers. Nestled within a 5,200-acre gated community, it offers a range of guest rooms, suites, and rentals. For instance, the rooms at The Inn & Club at Harbour Town are decorated with elegant furniture, comfy custom bedding, and Frette linens.
Golf is a major highlight of the resort. It is home to three championship golf courses, including the legendary Harbour Town Golf Links. You will also have access to a ton of amenities, including a 120-foot outdoor pool, a fitness center, a beach club, sports courts, and more. Dining is the last thing to worry about. You will discover multiple restaurants that showcase quintessential Lowcountry cuisine.
voco the Shelby
voco The Shelby is one of the best weekend getaways in Myrtle Beach, South Carolina. Opened in June 2025, the new boutique hotel is nestled on the front row of the vibrant shoreline. Echoing its surroundings, the interior is designed with sunny and delightful colors. The 241 guest rooms and suites feature stylish retro-inspired decor, playful details, a furnished private balcony, and Apotheke bath products.
The Shelby Beach Club is the main gathering space of the hotel, which boasts an outdoor pool, a lazy river, and shaded loungers. You will also have direct access to the shimmering beach, where you can soak in the sun or go for a splash. The Palm & Pebble is in charge of the dining experience on-site. Open throughout the day, the restaurant and bar offer coastal American cuisine alongside a variety of beverages.
Wild Dunes Resort
Wild Dunes Resort is one of the best weekend getaways in South Carolina. Nestled on the Isle of Palms, the resort occupies 1,600 acres of seaside estate. The property offers a range of accommodations, including guest rooms, suites, residences, and beach homes. For instance, the rooms at Sweetgrass Inn feature a contemporary coastal design, while the vacation rentals are perfect for larger groups and families.
The pool experience at Wild Dunes Resort is top-notch, featuring multiple outdoor pools for every type of guest. Home to two Tom Fazio–designed golf courses, you can also go for a round of golf with the Carolina coast in the backdrop. There are a ton of dining and drinking options on-site. You can savor everything from Coastal Provisions’ refined coastal dishes to Coastal Crust’s wood-fired Neapolitan pizzas.
French Quarter Inn
French Quarter Inn is one of the best weekend getaways in South Carolina. Set in Downtown Charleston, the boutique hotel is a tranquil urban retreat in the French Quarter district. Inspired by the rich history of the neighborhood, the interior embraces an old-world European glamour. The 50 rooms & suites are each outfitted with custom vintage furnishings, fine European linens, and an Italian marble bathroom.
During your stay, you will have access to a beautiful courtyard terrace and a fitness center with machines and free weights. You can also enjoy a complimentary gourmet breakfast every morning in the lobby, courtyard, or your room. There are no formal restaurants or bars inside the hotel, but it offers all-day flavored iced tea & snacks, afternoon wine & cheese receptions, and evening cookies & milk.
The George Hotel
The George Hotel is one of the best new weekend getaways in South Carolina. Located in the historic district of Georgetown, the boutique hotel occupies a beautiful waterfront position on the Hammock Coast. Taking cues from its surroundings, the interior showcases a vintage coastal charm. The 56 guest rooms & suites are each outfitted with whimsical patterns, custom headboards, and upscale amenities.
In addition, The George Hotel features two dining & drinking spaces on-site. For meals, The Independent is a seafood restaurant and raw bar highlighting the freshest ingredients of the Lowcountry. On the other hand, Eliza’s is a waterfront outdoor bar with refreshing drinks and bites. Situated right beside the Harborwalk Marina, you can also rent a boat and spend a day exploring the waters.
Beach House Hilton Head Island
Beach House Hilton Head Island is a vibrant weekend getaway in South Carolina. Nestled at the absolute waterfront, it offers one of the best boutique resort experiences on Hilton Head Island. The 202 rooms come in a crisp white design, finished with breezy furnishings, light wooden touches, Gilchrist & Soames bath products, and modern essentials. Some rooms also have ocean views and a private patio.
Recently refreshed, the heated outdoor pool and hot tub are a stunning gathering spot adorned with ample lounge beds and cabanas. Not to mention, you are literally right beside the picturesque Coligny Beach. You will also discover two dining & drinking spaces on-site. The Porch is the main all-day restaurant with comforting Southern favorites, while Tiki Hut is an iconic bar with live music & frosty cocktails.
The Dewberry
The Dewberry is a beautiful weekend getaway in Charleston, South Carolina. Nestled inside a historic landmark, the luxury boutique hotel showcases an elegant mix of old-world charm and modern comfort. It is home to 155 guest rooms & suites. They come in a white and neutral palette, complemented by classy dark wood furnishings, a bespoke Stickley botanical armoire, and a Vermont marble bathroom.
During your stay at The Dewberry, you will have access to a modern fitness studio and a revitalizing spa with treatments and massages. There are also two quality dining and drinking options on-site. Opening throughout the day, The Dining Room is a cozy space that serves everything from morning coffee to evening bites. On the rooftop, Citrus Club is a whimsical cocktail bar with panoramic city views.
also check out
