21c Museum Hotel St Louis is one of the best boutique hotels in St Louis, Missouri. Situated in the heart of downtown, it transformed a historic YMCA building into an art-filled urban escape. The public spaces preserved many of the original elements, while the 173 rooms and suites are refurbished with a modern flair. They feature lofty ceilings, large windows, original artwork, and pops of orange and green.
Besides, 21c Museum Hotel St Louis features a historic indoor lap pool, a 24-hour fitness center, a sauna, steam rooms, and treatments. Make sure you also check out the large in-house museum with curated exhibitions. For meals and drinks, Idol Wolf is the signature restaurant inspired by the rich culinary traditions of Spain, while Good Press is a laid-back cafe serving morning coffee and simple bites.















